Dangerous Side Effects of Ibuprofen in Children

Ibuprofen is the anti-inflammatory drug (NSAID) that is commonly used in children. It is often used instead of baby aspirin to treat fever, because aspirin has been associated with the development Reye's syndrome. Ibuprofen is used to treat pain, inflammation and fever. Ibuprofen use can be quite dangerous, however, for children who have certain existing conditions. It can also cause a very rare condition.

Asthma

• Children who suffer from mild to moderate asthma may be susceptible to ibuprofen-induced asthma attacks, although the chance of occurrence is small. Those susceptible to ibuprofen-induced asthma attacks are sensitive to the other non steroidal anti-inflammatory drugs as well, although ibuprofen is the least likely to cause an asthma attack.

Liver Failure

• Liver failure results in the reduced capability of the liver to detoxify the blood of drugs and other toxins. Ibuprofen can exacerbate liver failure and its associated signs and symptoms. Jaundice is the inability of the liver to remove bilirubin from the blood resulting in the yellowing of the skin and eye sclerae. Nausea and vomiting are two side effects that may also occur. The liver works with the kidneys to remove excess fluid from the body, so decreased liver function can lead to edema in the legs.

Renal Failure

• Children with renal failure should avoid taking ibuprofen as it can lead to further damage and exacerbate renal failure signs and symptoms. Ibuprofen decreases blood flow to the kidneys, which can decrease urine production and concentration. The kidneys' inability to remove excess fluid from the blood, coupled with decreased renal circulation, can result in edema in the legs or ascites in the abdomen.

Peptic Ulcer Disease

• Ibuprofen works by blocking the enzymes that produce prostaglandins. Prostaglandins are a chemical that induce pain and inflammation. They also promote mucus production in the stomach. It is this mucus production that prevents ulcers. Children with peptic ulcer disease have interruptions in the mucosal layer in the stomach. Ibuprofen can worsen this condition. Symptoms include a dull, achy pain that can be worsened with food. This pain occurs in the area of the belly button and above. It is important to note that the symptoms of peptic ulcer disease are different for children than for adults.

Stevens Johnson Syndrome

• Stevens Johnson Syndrome is a severe condition that causes lesions and blistering on the skin, and lesions in the mucosal membranes within the body. It is a rare condition that can lead to death from complications, especially if the condition is not recognized and ibuprofen use stopped. Ibuprofen is directly related to Stevens Johnson Syndrome. Some adults may also develop this condition.