Can you tell when pregnant if going to have a down syndrome child?

Yes, there are several screening tests and diagnostic tests that can be used to determine the risk of having a child with Down syndrome during pregnancy. These tests can provide information about the likelihood of a chromosomal abnormality, including Down syndrome.

Screening tests:

- First-trimester screening: This test combines maternal age, blood tests, and an ultrasound measurement to estimate the risk of Down syndrome and other chromosomal abnormalities. It usually involves a blood test to measure levels of certain hormones and an ultrasound to measure the thickness of the nuchal translucency (the fluid-filled space at the back of the fetus's neck).

- Second-trimester screening: This test, also called the quadruple screen or quad screen, measures levels of four substances in the mother's blood (alpha-fetoprotein, human chorionic gonadotropin, estriol, and inhibin A) and combines them with maternal age and other factors to calculate the risk of Down syndrome and other chromosomal abnormalities.

Diagnostic tests:

- Chorionic villus sampling (CVS): This test is usually performed between 10 and 13 weeks of pregnancy and involves taking a small sample of cells from the placenta to analyze the chromosomes. CVS can provide definitive information about the presence of chromosomal abnormalities, including Down syndrome.

- Amniocentesis: This test is usually performed between 15 and 20 weeks of pregnancy and involves taking a sample of the amniotic fluid surrounding the fetus to analyze the chromosomes. Amniocentesis can also provide definitive information about the presence of chromosomal abnormalities, including Down syndrome.

These screening tests and diagnostic tests can help provide information and guidance during pregnancy, allowing individuals to make informed decisions about their healthcare. It is important to discuss these tests with a healthcare provider to understand their accuracy, risks, and limitations, and to make decisions based on individual circumstances and preferences.