Is it safe to have pregnancy if mother has O negative blood group and father positive group?

It is generally safe for a mother with O-negative blood group to have a pregnancy with a father who has a positive blood group (A+, A-, B+, B-, AB+ or AB-). However, there is a potential risk of Rh incompatibility, which can occur when the mother is Rh-negative and the father is Rh-positive.

Rh incompatibility occurs when the Rh factor, a protein found on red blood cells, is incompatible between the mother and the fetus. In this case, the mother's immune system may recognize the Rh-positive red blood cells of the fetus as foreign and produce antibodies against them. These antibodies can cross the placenta and attack the fetal red blood cells, leading to a condition called erythroblastosis fetalis.

Erythroblastosis fetalis can cause serious health problems for the fetus, including anemia, jaundice, brain damage, and even death. However, it is important to note that Rh incompatibility can be prevented or effectively managed with proper medical care.

If the mother is Rh-negative and the father is Rh-positive, the doctor will closely monitor the pregnancy and administer Rh immunoglobulin (RhIg), also known as RhoGAM, to prevent the development of Rh antibodies. RhIg is usually given at specific times during pregnancy and after delivery to prevent Rh sensitization.

With regular prenatal care, monitoring, and appropriate use of RhIg, it is possible for a mother with O-negative blood group to have a safe and healthy pregnancy even if the father has a positive blood group.