Pristiq for Menopause

Pristiq (desvenlafaxine) is a prescription medication used for treatment of major depressive disorder and symptoms of menopause, including hot flashes, night sweats, and mood swings.

Dosing

• Desvenlafaxine is available in 50-mg and 100-mg tablets. The recommended dosage is 50-mg once per day (See References 1).

Function

• Desvenlafaxine blocks reuptake of two neurotransmitters, serotonin and norepinephrine, which increases the active levels of both in the brain (See References 1). Low serotonin and norepinephrine levels are associated with the development of depressive symptoms.

Interactions

• Desvenlafaxine should not be taken with an MAOI, since it may lead to serious and potentially fatal side effects. Caution is advised when taking desvenlafaxine with other medications that increase serotonin levels, since a serious condition called serotonin syndrome may result (See References 1).

Contraindications

• Caution is advised when prescribing desvenlafaxine to individuals with severely impaired liver or kidney functioning, since serious side effects may result (See References 1). Desvenlafaxine may induce mania or psychotic episodes in individuals with a history of bipolar disorder, schizophrenia, or another psychotic disorder.

Side Effects

• Common side effects include increased blood pressure, weight gain, muscle stiffness, insomnia, headache, dry mouth, upset stomach, constipation, loss of appetite, anxiety, dizziness, sweating, and sexual dysfunction (See References 1).

Withdrawal

• Cessation of desvenlafaxine, especially after long-term use, may cause withdrawal symptoms, including insomnia, anxiety, depression, diarrhea, irritability, nausea, and strange sensations resembling electric shocks (See References 1).