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Side Effects of Depo-Estradiol

Depo-estradiol is an estrogen injection or vaginal ring used to treat symptoms of menopause and low estrogen levels from hypogonadism. It can also be used to treat symptoms of prostate cancer in men.

  1. Common Side Effects

    • Some common side effects of Depo-Estradiol include nausea, vomiting, swollen breasts, acne or other skin changes, vaginal pain or dryness, decreased sex drive, depression and changes in menstrual periods.

    Serious Reactions

    • Less common serious reactions may include migraines, dementia, blood clots, or stroke. Use of vaginal ring may lead to toxic shock and bowel obstruction in rare cases.

    Increased Risk of Cancer

    • Depo-Estradiol may increase your risk of developing a condition called hyperplasia, which may lead to uterine cancer. Estrogen supplements may also increase the risk of breast cancer.

    Previous or Existing Conditions

    • If you have a history of stroke, circulation problems, a bleeding or clotting disorder or a history of breast or uterine cancer, you cannot use Depo-Estradoil. Do not use while pregnant or nursing.

    Drug Interactions

    • Certain antibiotics, including erytrhomycin, add to estrogen levels in the body when combined with Depo-Estradoil. Sedatives, including barbituates, may decrease the effectiveness of this medication.

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