What Are the Dangers of Zegerid?

Zegerid, a proton pump inhibitor (PPI) and sodium bicarbonate combination, is frequently prescribed for the treatment of gastroesophageal reflux disease (GERD). Although generally successful, the drug effects on the human metabolism carry some risks for certain users.

• Risky Mix

Combinations

• According to Drugs.com, Zegerid should not be taken by people who take Warfarin, Atazanavir, Diazepam, Tacrolimus or Phenytoin because the combination could alter the effects of either drug.

Allergic Reactions

• Zegerid may cause an allergic reaction in some users that manifests itself in swelling of the throat, lips, face or tongue or in difficulty breathing or hives.

Pregnancy Risk

• According to Medscape.com, Zegerid Oral has been linked to the formation of tumors in lactating rats and should be cautiously prescribed to women who are pregnant and who plan to breast-feed.

Side Effects

• At least 1 percent of people taking Zegerid experience side effects that include nausea, abdominal pain, constipation, vomiting and rash.

Low Calcium

• Zegerid should not be taken by anyone who is being treated for metabolic alkalosis or who has low levels of calcium in their blood.