| | Healthcare Industry | PPOs What does the medical abbreviation PFO mean? PFO stands for patent foramen ovale, a small opening between the two upper chambers of the heart that fails to close after birth, as it normally does. PPOs - Related Articles The Best Parasite Cleansers How to Lose Thirty Pounds Fast Going Green Food Experiments for Kids What Is Otogenic Pain? Lyme Disease Association Risks of Saccharin What Is Knee Joint Effusion?