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Difference Between Concerta & Vyvanse

Concerta (methylphenidate HCl) and Vyvanse (lisdexamfetamine dimesylate) are two medications used for treatment of attention deficit hyperactivity disorder (ADHD). Both medications are stimulants that are taken once daily.

  1. History

    • Concert was approved by the FDA in 2000. Vyvanse was approved by the FDA in 2007.

    Forms

    • Vyvanse is available in 30mg white and orange capsules, 50mg white and blue capsules and 70mg blue and orange capsules. Concerta is available in 18mg yellow tablets, 27mg gray tablets, 36mg white tablets and 54mg brownish-red tablets.

    Chemistry

    • Vyvanse is a pro-drug that must be metabolized by the body and converted into an amphetamine, which is an active drug. Concerta contains methylphenidate, a drug related to amphetamines, in its active form.

    Abuse

    • Vyvanse and Concerta are both schedule II controlled substances and have a high risk of abuse and dependence. Unlike Concerta, Vyvanse has a low potential of being abused by inhalation, since it is not converted into an active drug unless taken orally.

    Similar Medications

    • Concerta and Vyvanse have very similar side effects, including insomnia, dry mouth, agitation and loss of appetite. Not all individuals who experience side effects from Concerta will experience the same side effects from Vyvanse.

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