Zoloft for Bipolar Treatment

Zoloft (sertraline) is an antidepressant from the selective serotonin reuptake inhibitor (SSRI) class. It may be prescribed for treatment of depressive symptoms of bipolar disorder.

Use

• Zoloft and other antidepressants typically are used only for treating bipolar disorder when mood stabilizers have been ineffective at treating depressive symptoms. A mood stabilizer, such as lamotrigine or lithium, typically is taken concurrently with Zoloft in these cases.

Interactions

• Antipsychotic medications, which are commonly used for mood stabilization in treatment of bipolar disorder, may increase the risk of serotonin syndrome when taken with Zoloft. Symptoms of serotonin syndrome include hallucinations, agitation, changes in blood pressure and heart rate, impaired coordination, muscle tenseness or weakness, nausea, diarrhea and vomiting.

Side Effects

• Common side effects include sexual dysfunction, dry mouth, sweating, dizziness, headache, shakiness, fatigue, sleep disturbances and gastrointestinal problems.

Warning

• Caution is advised when prescribing Zoloft to individuals with bipolar disorder, as it may induce a manic episode. Close monitoring of symptoms is necessary during the first few weeks of treatment in order to assess changes in mood.

Alternatives

• Medication alternatives to Zoloft for treating depressive symptoms of bipolar disorder include other antidepressants, including bupropion or venlafaxine; atypical antipsychotics, such as olanzapine and quetiapine; lithium; and anticonvulsants, including vaproate or lamictal.