Side Effects of Antidepressants

The side effects of antidepressants may be temporary and resolve after a few weeks, or may last as long as the medications are being used. Antidepressants may cause side effects that include digestive problems, sleep issues and sexual problems. People who experience side effects from antidepressants should not suddenly quit taking them due to potential effects of sudden withdrawal, including a worsening of depression.

Nausea

• Nausea can occur during the first few weeks of taking antidepressants, and may be relieved by eating smaller meals more frequently, taking antacids or drinking clear fluids.

Weight Gain

• Antidepressants may cause weight gain from retaining fluids or as a result of improvement of poor appetites that were caused by the depression.

Sexual Dysfunction

• Decreased interest in sex, problems with erectile dysfunction and inability to have an orgasm are side effects of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs).

Fatigue

• Antidepressants may cause drowsiness and fatigue that may be mild to severe. This side effect can be minimized by taking medications close to bed time.

Insomnia

• While some people experience fatigue, others may get a boost of energy from antidepressants and experience insomnia.

Vision Problems

• Tricyclic antidepressants may dry the eyes and cause blurred or double vision, especially during the first few weeks of use.

Constipation

• Antidepressants can disrupt digestion and cause bloating, gas and constipation. According to the Mayo Clinic, this can be minimized by drinking plenty of fluids and eating foods high in fiber (see Resources below).