What Is the APRI Score?

What Is the APRI Score?

The APRI (AST to platelet ratio index) score is a noninvasive diagnostic tool used in patients with chronic liver disease. It is used to assess the degree of liver damage and scarring (fibrosis) without the need for a liver biopsy.

An APRI score of greater than 1.5 or higher is considered abnormal. An elevated APRI score indicates a higher likelihood of significant fibrosis or cirrhosis, which requires further investigation and management by a healthcare professional. The higher the APRI score, the more severe the liver damage or fibrosis is likely to be. However, it's important to note that the APRI score should be used in conjunction with other tests, imaging, and clinical findings for a comprehensive assessment of liver health.

The APRI score is calculated using a simple formula:

APRI = (AST/upper limit of normal AST value) / platelet count (x10^9)

Where:

AST: Aspartate aminotransferase, an enzyme found in the liver, high levels can indicate liver damage.

Upper limit of normal AST value: This value is specific to the laboratory performing the test and is based on the reference range established for healthy individuals.

Platelet count: The number of platelets in the blood.

The APRI score is advantageous over other noninvasive diagnostic tools because it does not require any special equipment or techniques, making it readily accessible and easy to perform in clinical practice. However, it is essential to note that the APRI score is not a definitive diagnostic test on its own, and further investigations or imaging (like ultrasound, elastography, or MRI) may be necessary for confirmation of liver fibrosis or cirrhosis.