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Proteins Similar to Collagen

Collagen is a protein part of the connective tissue or extracellular matrix, which surrounds and supports cells in mammalian tissues. Like collagen, other similar molecules present in the ECM have important roles such as giving support to cells, separating different tissues and regulating intercellular exchanges. The proteins fibronectin, fibrillin, laminin and elastin are examples of molecules similar in function to collagen.

  1. Fibronectin

    • Fibronectin works as a glue, attaching cells to their matrices. This protein contains at least six sites that show affinity for different substrates, such as collagen, fibrin and cell-surface receptors, according to The Medical Biochemistry Page website. In 2007, Harvard University researchers were able to grow heart muscle in vitro, using the protein fibronectin in the beginning of the procedure, according to a report by the Massachusetts Society for Medical Research.

    Laminin

    • Laminin is a large glycoprotein produced in the liver.Different forms of laminin are found in different stages of human development, as well as in distinct types of tissues. Laminin can interact with collagen type IV, as well as with a molecule called entactin. Abnormal laminins can cause development problems in muscles such as muscular dystrophy.

    Elastin and Fibrillin

    • Fibrilin and elastin function in parternish with collagen, allowing the connective tissues in blood vessels and other organs to stretch and then return to their original positions. According to the Williams Syndrome Foundation, the body stops making elastin soon after puberty. Williams Syndrome is a rare genetic condition which affects the normal production of elastin, and can cause the narrowing of the aorta.

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