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Coenzyme Q10 Analysis

Coenzyme Q10, also referred to as CoQ10, is a compound found within the cells of the human body. It is a major component in the production of ATP (adenosine triphosphate) which is the major energy source of cells. It is responsible for several different biological processes such as protein production and muscle contraction. Coenzyme Q10 also possesses antioxidant properties.

  1. Dosing

    • According to the Mayo Clinic, adult doses of CoQ10 are 50 to 1,200 milligrams daily. The doses will be taken by mouth several times a day. Doses are dependent on the condition in which coenzyme Q10 is being used to treat or prevent.

    Uses

    • Coenzyme Q10 helps to improve the immune system, increase energy and eliminate free radicals from the body. According to the University of Maryland Medical Center, this compound, either alone or when combined with other nutritional supplements and drug therapies, may help to treat or prevent certain medical conditions. These include heart failure, heart disease, high cholesterol, high blood pressure, chemotherapy-related heart damage, diabetes, periodontal disease and breast cancer. Taking coenzyme Q10 before heart surgery may also help decrease free radical related damage, decrease irregular heart beat during recovery, and strengthen heart function.

    Side Effects

    • Patients who take coenzyme Q10 may experience side effects. According to the Mayo Clinic, these are typically brief and mild and will not require any treatment. The side effects can include nausea, flu-like symptoms, vomiting, fatigue, stomach upset, increased sensitivity to light, heartburn, irritability, diarrhea, itching, loss of appetite, dizziness, rash, headache and insomnia.

    Risks and Warnings

    • According to the Mayo Clinic, patients with low blood sugar issues or diabetes should use caution when taking coenzyme Q10 because it can decrease blood sugar levels. Coenzyme Q10 can increase bruising or bleeding because this compound may lower blood platelet levels, so patients with bleeding disorders should use caution. Coenzyme Q10 may also lower blood pressure.

      Other issues that may occur with taking coenzyme Q10 include liver enzyme elevation, thyroid hormone level alteration, and a decrease in triglyceride or cholesterol levels. During intense exercise, the flow of blood and oxygen may decrease, resulting in organ damage, so patients taking CoQ10 supplements are discouraged from participating in vigorous exercise.

    Positive Drug Interactions

    • CoQ10 may increase the effectiveness of some medications, while decreasing that of others. According to the University of Maryland Medical Center, the toxic effects of certain chemotherapy medications such as Adriamycin and Cerubidin may be decreased by coenzyme Q10. It may increase the effectiveness of some blood pressure drugs such as Cardizem, Nitrobid, Lopressor, Vasotec, Toprol and Nitrostat.

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