What happen when the circulatory system cannot transport substance needed by body cells and carry waste from cells?

1. Inadequate Oxygen Delivery:

- Tissue hypoxia: When the circulatory system fails to deliver sufficient oxygen to body cells, tissues experience hypoxia, leading to cellular dysfunction and damage.

- Organ failure: Prolonged hypoxia can cause organ failure as vital organs, such as the heart, brain, kidneys, and liver, are deprived of oxygen.

2. Accumulation of Waste Products:

- Waste buildup: As the circulatory system fails to remove metabolic waste products from cells, these substances accumulate in the body.

- Metabolic acidosis: The buildup of waste products, particularly carbon dioxide and lactic acid, can lead to metabolic acidosis, disrupting cellular processes and pH balance.

3. Impaired Nutrient Delivery:

- Malnutrition: The circulatory system plays a crucial role in transporting nutrients to cells throughout the body. Impaired circulation can result in malnutrition and deficiencies in essential nutrients.

- Growth retardation: In children, inadequate nutrient delivery due to circulatory issues can lead to growth retardation and developmental problems.

4. Tissue Damage and Necrosis:

- Tissue death: Prolonged lack of oxygen and accumulation of waste products can cause tissue damage, leading to necrosis (cell death).

- Gangrene: In severe cases, tissue death and necrosis can progress to gangrene, requiring surgical removal of affected tissues.

5. Cardiovascular Complications:

- Heart failure: The circulatory system is directly linked to the heart. Impaired circulation can strain the heart, leading to heart failure.

- Stroke: Inadequate blood flow to the brain can cause a stroke, damaging brain tissue and affecting neurological functions.

6. Peripheral Artery Disease:

- Reduced blood flow to the limbs due to circulatory problems can manifest as peripheral artery disease (PAD). Symptoms may include leg pain, numbness, and poor wound healing.

7. Deep Vein Thrombosis (DVT):

- Impaired circulation can increase the risk of blood clot formation in deep veins, leading to deep vein thrombosis (DVT). DVT can cause pain, swelling, and the risk of pulmonary embolism.

8. Systemic Disorders:

- Sepsis: Severe circulatory problems can contribute to sepsis, a life-threatening condition where the body's response to infection damages its own tissues.

9. Multi-Organ Failure:

- In extreme cases, the cumulative effects of circulatory failure can result in multi-organ failure, where several vital organs simultaneously cease to function properly, often leading to death.