How long does nicotine stay in your cheek cells?

Cotinine, a major metabolite of nicotine, can be detected in oral fluids for up to 4 days after exposure. Cotinine has been detected in buccal cells (cheek cells) for up to 14 days after exposure. However, the exact length of time that nicotine and its metabolites remain detectable in cheek cells can vary depending on a number of factors, such as the amount of nicotine consumed, the frequency of consumption, and the individual's metabolism.