How can tissue rejection be prevented?

Tissue rejection is the immune system's response to foreign tissue, such as an organ transplant. It can be prevented by:

* Immunosuppression: Drugs that suppress the immune system can be given to prevent rejection. These drugs include corticosteroids, calcineurin inhibitors, and mycophenolate mofetil.

* HLA matching: Organs that are transplanted from a donor who is a close genetic match to the recipient are less likely to be rejected. This is because the recipient's immune system is less likely to recognize the transplanted organ as foreign.

* Pre-transplant conditioning: Some patients may undergo pre-transplant conditioning, such as radiation therapy or chemotherapy, to reduce the risk of rejection. This treatment can help to weaken the recipient's immune system and make it less likely to attack the transplanted organ.

* Antibody induction therapy: Some patients may receive antibody induction therapy, which involves giving them antibodies that target specific immune cells that are involved in rejection. This therapy can help to reduce the risk of rejection in high-risk patients.

* Donor-specific transfusion: In some cases, patients may receive a transfusion of blood from the donor prior to transplantation. This can help to expose the recipient's immune system to the donor's antigens and make it less likely to attack the transplanted organ.